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This prolonged transit allows excessive water absorption, resulting in harder, drier stools that are more difficult to pass

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Cardiovascular (Heart and Blood Vessel) Complications In rare but serious cases, B12 replacement can lead to heart and blood vessel problems: Shortness of breath Peripheral edema (swelling in legs and arms) Rapid weight gain Pulmonary edema (fluid in lungs) Congestive heart failure (heart cannot pump effectively) Blood clots in vessels These complications arise from increased blood volume, thicker blood, and sudden changes in how hard the heart needs to work

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Tirzepatide causes gastrointestinal side effects (nausea, vomiting, diarrhoea) in 3045% of patients during dose titration, typically resolving within 48 weeks

For many patients, pausing medication is a short-term step that greatly improves safety and reduces the likelihood of complications